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Category:Video games developed in JapanHeat shock protein expression is not a feature of estrogen receptor-positive breast tumors with an invasive component and stromal microenvironment.
Breast cancer is a heterogeneous disease with a variety of clinicopathologic subtypes and variable responsiveness to hormonal or cytotoxic therapy. The interaction of cancer cells with stromal cells is important for tumor progression. The aim of this study was to compare the expression of heat shock proteins (HSPs) 72 and 90 in estrogen receptor (ER) positive invasive breast carcinoma of different types and in the stromal microenvironment. Paraffin-embedded tissues from 170 breast carcinomas were used in the study. Two hundred and forty-three normal human breast tissue samples served as controls. ER and PR protein expression was evaluated immunohistochemically. Stromal HSPs were evaluated by the enzyme-linked immunosorbent assay (ELISA) and Western blot technique. Stromal HSP 72 and 90 expression was found in 47.7% and 55.9% of the cases, respectively. Stromal HSP 72 and 90 expression was found to be significantly higher in tumors of different grades than in grade I tumors (P Q:
NServiceBus - Startup exceptions handled but persistence error not
I've built an NServiceBus-based app that's working well
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